Current breast cancer clinical trials

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Amadori D et al. Disease-free survival advantage of adjuvant cyclophosphamide, methotrexate and fluorouracil in patients with node-negative, rapidly proliferating breast cancer: A randomized multicenter study. J Clin Oncol 2000;18:3125-34. Abstract

Antman KH. A critique of the eleven randomised trials of high-dose chemotherapy for breast cancer. Eur J Cancer 2001;37(2):173-179. Abstract

Bang SM et al. Adjuvant doxorubicin and cyclophosphamide versus cyclophosphamide, methotrexate and 5-fluorouracil chemotherapy in premenopausal women with axillary lymph node positive breast carcinoma. Cancer 2000;89:2521-6. Abstract

Benefit of a high-dose epirubicin regimen in adjuvant chemotherapy for node-positive breast cancer patients with poor prognostic factors: 5-year follow-up results of French Adjuvant Study Group 05 randomized trial. J Clin Oncol 2001;19:602-11. Abstract

Bontenbal M et al. Value of estrogenic recruitment before chemotherapy: First randomized trial in primary breast cancer. J Clin Oncol 2000;18:734-42. Abstract

Braun S et al. Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J Clin Oncol 2000;18:80-6. Abstract

Brezden CB et al. Cognitive function in breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 2000;18:2695-701. Abstract

Buban GM et al. Influences on oncologists’ adoption of new agents in adjuvant chemotherapy of breast cancer. J Clin Oncol 2001;19:954-9. Abstract

Chang J. Chemotherapy dose reduction and delay in clinical practice. Evaluating the risk to patient outcome in adjuvant chemotherapy for breast cancer. Eur J Cancer 2000;36(Suppl 1):S11-14. Abstract

Chaplain G et al. Increased risk of acute leukemia after adjuvant chemotherapy for breast cancer: A population-based study. J Clin Oncol 2000;18:2836-42. Abstract

Colleoni M et al. Early start of adjuvant chemotherapy may improve treatment outcome for premenopausal breast cancer patients with tumors not expressing estrogen receptors. The International Breast Cancer Study Group. J Clin Oncol 2000;18:584-90. Abstract

Crivellari D et al. Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: The International Breast Cancer Study Group Trial VII. J Clin Oncol 2000;18:1412-22. Abstract

Demark-Wahnefried W et al. Changes in weight, body composition and factors influencing energy balance among premenopausal breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol 2001;19:2381-9. Abstract

Erselcan T et al. Subclinical cardiotoxicity following adjuvant dose-escalated FEC, high-dose chemotherapy or CMF in breast cancer. Br J Cancer 2000;82(4):777-781. Abstract

Extermann M et al. What threshold for adjuvant therapy in older breast cancer patients? J Clin Oncol 2000;18:1709-17. Abstract

Fisher B et al. Prognosis and treatment of patients with breast tumors of one centimeter or less and negative axillary lymph nodes. J Natl Cancer Inst 2001;93:112-20. Abstract

Fumoleau P et al. Intensification of adjuvant chemotherapy: 5-year results of a randomized trial comparing conventional doxorubicin and cyclophosphamide with high-dose mitoxantrone and cyclophosphamide with filgrastim in operable breast cancer with 10 or more involved axillary nodes. J Clin Oncol 2001;19:612-20. Abstract

Hortobagyi GN et al. Randomized trial of high-dose chemotherapy and blood cell autografts for high-risk primary breast carcinoma. J Natl Cancer Inst 2000;92:225-33. Abstract

Janicke F et al. Randomized adjuvant chemotherapy trial in high-risk, lymph node-negative breast cancer patients identified by urokinase-type plasminogen activator and plasminogen activator inhibitor type 1. J Natl Cancer Inst 2001;93:913-20. Abstract

Jansen SJ et al. Patients’ preferences for adjuvant chemotherapy in early-stage breast cancer: Is treatment worthwhile? Br J Cancer 2001;84(12):1577-1585. Abstract

Joly F et al. Long-term quality of life in premenopausal women with node-negative localized breast cancer treated with or without adjuvant chemotherapy. Br J Cancer 2000;83(5):577-582. Abstract

Lichtman SM, Villani G. Chemotherapy in the elderly: Pharmacologic considerations. Cancer Control 2000;7(6):548-56. Full-Text

Loprinzi CL, Thome SD. Understanding the utility of adjuvant systemic therapy for primary breast cancer. J Clin Oncol 2001;19:972- 9. Abstract

Mayers C, Panzarella T, Tannock IF. Analysis of the prognostic effects of inclusion in a clinical trial and of myelosuppression on survival after adjuvant chemotherapy for breast carcinoma. Cancer 2001;91:2246-57. Abstract

Meinardi MT et al. Prospective evaluation of early cardiac damage induced by epirubicin-containing adjuvant chemotherapy and locoregional radiotherapy in breast cancer patients. J Clin Oncol 2001;19:2746-53. Abstract

Menard S et al. Response to cyclophosphamide, methotrexate and fluorouracil in lymph node-positive breast cancer according to HER2 overexpression and other tumor biologic variables. J Clin Oncol 2001;19:329-35. Abstract

Piccart MJ et al. Phase III trial comparing two dose levels of epirubicin combined with cyclophosphamide with cyclophosphamide, methotrexate and fluorouracil in node-positive breast cancer. J Clin Oncol 2001;19:3103-10. Abstract

Pierga JY et al. Effect of adjuvant chemotherapy on outcome in patients with metastatic breast carcinoma treated with first-line doxorubicin-containing chemotherapy. Cancer 2001;91:1079-89. Abstract

Poikonen P et al. Prognostic effect of amenorrhoea and elevated serum gonadotropin levels induced by adjuvant chemotherapy in premenopausal node-positive breast cancer patients. Eur J Cancer 2000;36(1):43-48. Abstract

Ravdin PM et al. Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Clin Oncol 2001;19:980-91. Abstract

Shapiro CL et al. Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer. J Clin Oncol 2001;19:3306-11. Abstract

Wolff AC, Davidson NE. Primary systemic therapy in operable breast cancer. J Clin Oncol 2000;18:1558-69. Abstract

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OTHER RESOURCES

NCI Bibliography of Adjuvant Therapy for Breast Cancer: July 1995-July 2000 Weblink

Mayo Clinic’s webtool for determining adjuvant breast cancer treatment benefits Weblink

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Additional Sections:
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |

Section 7:
Optimal use of adjuvant chemotherapy
Page 1
Page 2
Page 3
Select Publications
· Other Resources

 

Additional Sections:

1
Breast cancer clinical trials
2
Management of the axilla
3
Radiation therapy for primary breast cancer
4
Optimal use of adjuvant tamoxifen and ovarian ablation
5
Aromatase inhibitors in the adjuvant setting
6
Faslodex: An estrogen receptor downregulator
7
Optimal use of adjuvant chemotherapy
8
Herceptin as adjuvant therapy
9
Neoadjuvant systemic therapy
10
Bisphosphonates as adjuvant therapy
11
Other breast cancer clinical trials
12
Breast cancer training opportunities and clinical trials at Northwestern University
 

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