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Estrogen receptor biology and mechanisms for the development of resistance to endocrine therapy

Atanaskova N et al. MAP kinase/estrogen receptor cross-talk enhances estrogen-mediated signaling and tumor growth but does not confer tamoxifen resistance. Oncogene 2002;21:4000-8. Abstract

Berry DA et al. HER-2/neu and p53 expression versus tamoxifen resistance in estrogen receptorpositive, node-positive breast cancer. J Clin Oncol 2000;18:3471-9. Abstract

Bieche I et al. ERBB2 status and benefit from adjuvant tamoxifen in ERalpha-positive postmenopausal breast carcinoma. Cancer Lett 2001;174:173-8. Abstract

Brinkman A et al. BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst 2000;92:112-20. Abstract

Brockdorff BL et al. Increased expression of cytochrome p450 1A1 and 1B1 genes in anti-estrogenresistant human breast cancer cell lines. Int J Cancer 2000;88:902-6. Abstract

Campbell RA et al. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance. J Biol Chem 2001;276:9817-24. Abstract

Cheung KL et al. Selection of primary breast cancer patients for adjuvant endocrine therapy--is oestrogen receptor alone adequate? Breast Cancer Res Treat 2001;65(2):155-62. Abstract

Chung YL et al. Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer. Int J Cancer 2002;97:306-12. Abstract

Clarke R et al. Molecular and pharmacological aspects of antiestrogen resistance. J Steroid Biochem Mol Biol 2001;76:71-84. Abstract

Donovan JC et al. Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 2001;276:40888-95. Abstract

Dorssers LC et al. Tamoxifen resistance in breast cancer: Elucidating mechanisms. Drugs 2001;61:1721-33. Abstract

Dowsett M et al. HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer. Cancer Res 2001;61:8452-8. Abstract

Geisler J, Lonning PE. Resistance to endocrine therapy of breast cancer: Recent advances and tomorrow's challenges. Clin Breast Cancer 2001;1:297-308; discussion 309. Abstract

Goss PE, Strasser K. Tamoxifen resistant and refractory breast cancer: The value of aromatase inhibitors. Drugs 2002;62:957-66. Abstract

Graham JD et al. Nuclear receptor conformation, coregulators, and tamoxifen-resistant breast cancer. Steroids 2000;65:579-84. Abstract

Graham JD et al. Thoughts on tamoxifen resistant breast cancer. Are coregulators the answer or just a red herring? J Steroid Biochem Mol Biol 2000;74:255-9. Abstract

Gu Z et al. Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780). Cancer Res 2002;62:3428-37. Abstract

Hori M et al. Overexpression of mitogen-activated protein kinase superfamily proteins unrelated to Ras and AF-1 of estrogen receptor alpha mutation in advanced stage human breast cancer. Pathol Res Pract 2000;196:817-26. Abstract

Kato S. Estrogen receptor-mediated cross-talk with growth factor signaling pathways. Breast Cancer 2001;8:3-9. Abstract

Kenny FS et al. Change in expression of ER, bcl-2 and MIB1 on primary tamoxifen and relation to response in ER positive breast cancer. Breast Cancer Res Treat 2001;65(2):135-44. Abstract

Knoop AS et al. Value of epidermal growth factor receptor, HER2, p53, and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast cancer patients. J Clin Oncol 2001;19:3376-84. Abstract

Kunisue H et al. Anti-HER2 antibody enhances the growth inhibitory effect of anti-oestrogen on breast cancer cells expressing both oestrogen receptors and HER2. Br J Cancer 2000;82:46-51. Abstract

Kurokawa H, Arteaga CL. Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer. Clin Cancer Res 2001;7:4436s-4442s; discussion 4411s-4412s. Abstract

Kurokawa H et al. Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Res 2000;60:5887-94. Abstract

Lee AV et al. Cross-talk among estrogen receptor, epidermal growth factor, and insulin-like growth factor signaling in breast cancer. Clin Cancer Res 2001;7:4429s-4435s; discussion 4411s-4412s. Abstract

Lee ES et al. Cross-resistance of triphenylethylene-type antiestrogens but not ICI 182,780 in tamoxifen-stimulated breast tumors grown in athymic mice. Clin Cancer Res 2000;6:4893-9. Abstract

Levenson AS et al. Control of the estrogen-like actions of the tamoxifen-estrogen receptor complex by the surface amino acid at position 351. J Steroid Biochem Mol Biol 2001;76:61-70. Abstract

Leveque J et al. Benefits of complete polyamine deprivation in hormone responsive and hormone resistant MCF-7 human breast adenocarcinoma in vivo. Anticancer Res 2000;20:97-101. Abstract

McClelland RA et al. Enhanced epidermal growth factor receptor signaling in MCF7 breast cancer cells after long-term culture in the presence of the pure antiestrogen ICI 182,780 (Faslodex). Endocrinology 2001;142:2776-88. Abstract

Nichols M, McCarty KS Jr. Functional mutations of estrogen receptor protein: Assay for detection. Breast Cancer Res Treat 2002;72:61-8. Abstract

Nicholson RI et al. Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocr Relat Cancer 2001;8:175-82. Abstract

Osborne CK et al. Estrogen receptor: Current understanding of its activation and modulation. Clin Cancer Res 2001;7:4338s-4342s; discussion 4411s-4412s. Abstract

Santen R et al. Adaptive hypersensitivity to estradiol: Potential mechanism for secondary hormonal responses in breast cancer patients. J Steroid Biochem Mol Biol 2001;79(1-5):115-25. Abstract

Speirs V, Kerin MJ. Prognostic significance of oestrogen receptor beta in breast cancer. Br J Surg 2000;87:405-9. Abstract

Wakeling AE et al. Prospects for combining hormonal and nonhormonal growth factor inhibition. Clin Cancer Res 2001;7:4350s-4355s; discussion 4411s-4412s. Abstract

Yoshida T et al. Distinct mechanisms of loss of estrogen receptor alpha gene expression in human breast cancer: Methylation of the gene and alteration of transacting factors. Carcinogenesis 2000;21:2193-201. Abstract

 

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Joyce O'Shaughnessy, MD
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Daniel F Hayes, MD
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Melody A Cobleigh, MD
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John F Robertson, MD, FRCS
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