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Adjuvant endocrine therapy in premenopausal patients

Aebi S et al. Is chemotherapy alone adequate for young women with oestrogen-receptor-positive breast cancer? Lancet 2000;355(9218):1869-74. Abstract

Baum M et al. Management of premenopausal women with early breast cancer: Is there a role for goserelin? Proc ASCO 2001; Abstract 103.

Boccardo F et al. Cyclophosphamide, methotrexate, and fluorouracil versus tamoxifen plus ovarian suppression as adjuvant treatment of estrogen receptor-positive pre-/perimenopausal breast cancer patients: Results of the Italian Breast Cancer Adjuvant Study Group 02 randomized trial. J Clin Oncol 2000;18:2718-27. Abstract

Celio L et al. Premenopausal breast cancer patients treated with a gonadotropin-releasing hormone analog alone or in combination with an aromatase inhibitor: A comparative endocrine study. Anticancer Res 1999;19:2261-8. Abstract

Cheung KL et al. The combined use of goserelin and anastrozole as second line endocrine therapy in premenopausal women with advanced breast cancer - A study of its clinical and endocrine effects. Proc ASCO 2001; Abstract 1937.

Colleoni M et al. Early start of adjuvant chemotherapy may improve treatment outcome for premenopausal breast cancer patients with tumors not expressing estrogen receptors. The International Breast Cancer Study Group. J Clin Oncol 2000;18(3):584-90. Abstract

Davidson N et al. Effect of chemohormonal therapy in pre-menopausal, node (+), receptor (+) breast cancer: An Eastern Cooperative Oncology Group phase III Intergroup trial (E5188, INT-0101). Proc ASCO 1999; Abstract 249A, 67A.

Dowsett M et al. Vorozole results in greater estrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer. Breast Cancer Res Treat 1999;56:25-34. Abstract

Early Breast Cancer Trialists’ Collaborative Group. Ovarian ablation for early breast cancer. Cochrane Database Syst Rev 2000;CD000485. Abstract

Early Breast Cancer Trialists’ Collaborative Group. Ovarian ablation in early breast cancer: Overview of the randomised trials. Lancet 1996;348:1189-96. Abstract

Ejlertsen B et al. Comparable effect of ovarian ablation (OA) and CMF chemotherapy in premenopausal hormone receptor positive breast cancer patients (PRP). Proc ASCO 1999. Abstract

Forward D et al. Combined use of goserelin (Zoladex) and anastrozole (Arimidex) in premenopausal women with metastatic breast cancer (MBC). Proc ASCO 2000; Abstract 582.

Gnant M et al. Changes in bone mineral density caused by anastrozole or tamoxifen in combination with goserelin (± zoledronate) as adjuvant treatment for hormone receptor-positive premenopausal breast cancer: Results of a randomized multicenter trial. Breast Cancer Res Treat 2002; Abstract 12.

Goldhirsch A et al. Adjuvant therapy for very young women with breast cancer: Need for tailored treatments. J Natl Cancer Inst Monogr 2001;(30):44-51. Abstract 582.

Goss PE, Strasser K. Aromatase inhibitors in the treatment and prevention of breast cancer. J Clin Oncol 2001;19:881-94. Abstract

Hoffken K, Kath R. The role of LH-RH analogues in the adjuvant and palliative treatment of breast cancer. Recent Results Cancer Res 2000;153:61-70. Abstract

Houghton J et al. The ZIPP trial of adjuvant Zoladex in premenopausal patients with early breast cancer: An update at five years. Proc ASCO 2000; Abstract 359.

Jakesz R. Comparison of adjuvant therapy with tamoxifen and goserelin vs. CMF in premenopausal stage I and II hormone-responsive breast cancer patients: Four-year results of Austrian Breast Cancer Study Group (ABCSG) Trial 5. Proc ASCO 1999; Abstract 250.

Jakesz R et al. Chemotherapy versus hormonal adjuvant treatment in premenopausal patients with breast cancer. Eur J Cancer 2002;38(3):327-32. Abstract

Jakesz R et al. Randomized adjuvant trial of tamoxifen and goserelin versus cyclophosphamide, methotrexate, and Fluorouracil: Evidence for the superiority of treatment with endocrine blockade in premenopausal patients with hormone-responsive breast cancer-austrian breast and colorectal cancer study group trial 5. J Clin Oncol 2002;20(24):4628-35. Abstract.

Jonat W et al. Goserelin versus cyclophosphamide, methotrexate, and fluorouracil as adjuvant therapy in premenopausal patients with node-positive breast cancer: The Zoladex Early Breast Cancer Research Association Study. J Clin Oncol 2002;20(24):4621-7. Abstract.

Kaufmann M et al. Updated survival results from the Zebra trial. Breast Cancer Res Treat 2002; Abstract 254.

Klijn JG et al. Combined tamoxifen and luteinizing hormone-releasing hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer: A meta-analysis of four randomized trials. J Clin Oncol 2001;19:343-53. Abstract

Love RR et al. Oophorectomy and tamoxifen adjuvant therapy in premenopausal Vietnamese and Chinese women with operable breast cancer. J Clin Oncol 2002;20(10):2559-66. Abstract

Michaud LB, Buzdar AU. Complete estrogen blockade for the treatment of metastatic and early stage breast cancer. Drugs Aging 2000;16:261-71. Abstract

Michaud LB et al. Combination endocrine therapy in the management of breast cancer. Oncologist 2001;6(6):538-46. Abstract

Milla-Santos A et al. A randomized trial of goserelin (Zoladex™) + tamoxifen versus goserelin + anastrozole (Arimidex™) ) in pre/perimenopausal patients with hormone dependent advanced breast cancer. Breast Cancer Res Treat 2002;No abstract available.

Muss HB. Factors used to select adjuvant therapy of breast cancer in the United States: an overview of age, race, and socioeconomic status. J Natl Cancer Inst Monogr 2001;(30):52-5. Abstract 289.

Parulekar W et al. Incidence and prognostic impact of amenorrhea during adjuvant therapy in high risk premenopausal breast cancer patients: Analysis of a National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) phase III study. Proc ASCO 2001; Abstract 97.

Recchia F et al. Goserelin as ovarian protection in the adjuvant treatment of premenopausal breast cancer: A phase II pilot study. Anticancer Drugs 2002;13(4):417-24. Abstract.

Sayer HG et al. Bone mineral density in premenopausal patients in a randomized trial of adjuvant endocrine therapy (ZIPP-TRIAL). Proc ASCO 2001; Abstract 96.

Sverrisdottir A et al. Premenopausal breast cancer: Chemotherapy and endocrine therapy. Drugs 2002;62(14):2025-38. Abstract.

 

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Larry Norton, MD
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Gabriel N Hortobagyi, MD
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Nancy E Davidson, MD
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