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Breast Cancer Update: A CME Audio Series and Activity

STATMENT OF NEED / TARGET AUDIENCE
Breast cancer is one of the most rapidly evolving fields in medical oncology. Published results from a plethora of ongoing clinical trials lead to the continuous emergence of new therapeutic agents and changes in the indications for existing treatments. In order to offer optimal patient care — including the option of clinical trial participation — the practicing medical oncologist must be well informed of these advances.

To bridge the gap between research and patient care, Breast Cancer Update utilizes one-on-one discussions with leading oncology investigators. By providing access to the latest research developments and expert perspectives, this CME program assists medical oncologists in the formulation of up-to-date clinical management strategies.

Issue 7, 2002 of Breast Cancer Update consists of discussions with four oncology research leaders on a variety of important issues, including the role of trastuzumab in treating HER2-positive metastatic disease, the toxicities of trastuzumab and trastuzumab in combination with other chemotherapeutic regimens, the sequencing of treatment for the elderly patient, current clinical trials for the elderly, adjuvant hormonal therapy and the management of the patient at high risk for breast cancer.

EDUCATIONAL OBJECTIVES
Upon completion of this activity, participants should be able to:

  • Evaluate the survival advantage observed in the trastuzumab pivotal trial in order to determine the importance of considering earlier treatment with trastuzumab in patients with HER2-positive metastatic breast cancer.
  • Distinguish among the various approaches to sequencing and combining therapeutic agents in order to define the most efficacious and least toxic treatment regimens for patients with metastatic disease.
  • Understand the risks and benefits of combining chemotherapy with trastuzumab in order to select the most effective, least toxic regimens for HER2-positive patients.
  • Apply the findings of the 2002 ASCO technology assessment to determine the appropriateness of using aromatase inhibitors as adjuvant therapy for patients with ER/PR receptor–positive breast cancer.
  • Identify and manage patients who are at high risk for developing breast cancer using the findings from the 2002 ASCO technology assessment of pharmacologic interventions for breast cancer risk reduction.

ACCREDITATION STATEMENT
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Postgraduate Institute for Medicine and NL Communications, Inc. The Postgraduate Institute for Medicine is accredited by the ACCME to provide continuing medical education for physicians.

DESIGNATION STATEMENT
The Postgraduate Institute for Medicine designates this educational activity for a maximum of 3 hours in category 1 credit toward the AMA Physician's Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the activity.

FACULTY DISCLOSURE STATEMENTS
The Postgraduate Institute for Medicine has a conflict of interest policy that requires course faculty to disclose any real or apparent commercial financial affiliations related to the content of their presentations/materials. It is not assumed that these financial interests or affiliations will have an adverse impact on faculty presentations; they are simply noted in this supplement to fully inform participants.

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Editor's Note
Debu Tripathy, MD
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Hyman B Muss, MD
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Clifford A Hudis, MD
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Rowan T Chlebowski, MD, PhD
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