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Use of bisphosphonates in breast cancer

Ali SM et al. Safety and efficacy of bisphosphonates beyond 24 months in cancer patients. J Clin Oncol 2001;19:3434-7. Abstract

Berenson JR. Zoledronic acid in cancer patients with bone metastases: Results of Phase I and II trials. Semin Oncol 2001;28:25-34. Abstract

Bryce CJ et al. Does short-term, intravenous, low-dose clodronate, administered with adjuvant chemotherapy for premenopausal breast cancer, reduce bone loss in the first year in patients? Proc ASCO 2002;Abstract 270.

Chlebowski RT. Factors influencing the role of bisphosphonates in breast cancer management. Semin Oncol 2001;28:42-8. Abstract

Coleman RE. Should bisphosphonates be the treatment of choice for metastatic bone disease? Semin Oncol 2001;28:35-41. Abstract

Coleman RE, Seaman JJ. The role of zoledronic acid in cancer: Clinical studies in the treatment and prevention of bone metastases. Semin Oncol. 2001;28:11-6. Abstract

Diel IJ. Bisphosphonates in the prevention of bone metastases: Current evidence. Semin Oncol 2001;28:75-80. Abstract

Diel IJ, Mundy GR. Bisphosphonates in the adjuvant treatment of cancer: Experimental evidence and first clinical results. International Bone and Cancer Study Group (IBCG). Br J Cancer 2000;82:1381-6. Abstract

Gralow JR. The role of bisphosphonates as adjuvant therapy for breast cancer. Curr Oncol Rep 2001;3:506-15. Abstract

Hillner BE et al. American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. American Society of Clinical Oncology Bisphosphonates Expert Panel. J Clin Oncol 2000;18:1378-91. Abstract

Hillner BE et al. Pamidronate in prevention of bone complications in metastatic breast cancer: A cost-effectiveness analysis. J Clin Oncol 2000;18:72-9. Abstract

Jagdev SP et al. The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: Evidence for synergy with paclitaxel. Br J Cancer 2001;84:1126-34. Abstract

Nikolic-Tomasevic Z et al. Tumor 'flare' hypercalcemia--an additional indication for bisphosphonates? Oncology 2001;60:123-6. Abstract

Paterson AH. Adjuvant bisphosphonate therapy: The future. Semin Oncol 2001;28:81-5. Abstract

Perez EA. Metastatic bone disease in breast cancer: The patient's perspective. Semin Oncol 2001;28:60-3. Abstract

Powles TJ et al. A randomised placebo controlled trial to evaluate the effect of the bisphosphonate, clodronate, on the incidence of metastases and mortality in patients with primary operable breast cancer. Breast Cancer Res Treat 2001;Abstract 1.

Rosen LS et al. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial. Cancer J 2001;7:377-87. Abstract

Saarto T et al. Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial. J Clin Oncol 2001;19:10-7. Abstract

Saarto T et al. The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer. Br J Cancer 2001;84:1047-51. Abstract

Tripathy D. Bisphosphonates in oncology: Breast cancer and beyond. Semin Oncol 2001;28:86-91. Abstract

Van Poznak C. How are bisphosphonates used today in breast cancer clinical practice? Semin Oncol 2001;28:69-74. Abstract

Vehmanen L et al. Long-term impact of chemotherapy-induced ovarian failure on bone mineral density (BMD) in premenopausal breast cancer patients. The effect of adjuvant clodronate treatment. Eur J Cancer 2001;37:2373-8. Abstract

Fulvestrant (ICI 182,780; Faslodex®)

Cheung KL, Robertson JF. Fulvestrant. Expert Opin Investig Drugs 2002;11:303-308. Abstract

Curran M, Wiseman L. Fulvestrant. Drugs 2001;61:807-13; discussion 814. Abstract

Elkak AE, Mokbel K. Pure antiestrogens and breast cancer. Curr Med Res Opin 2001;17:282-9. Abstract

Erikstein B et al. ICI 182,780 (‘Faslodex’) 250 mg monthly intramuscular (IM) injection shows consistent PK profile when given as either 1 x 5ml or 2 x 2.5 ml injections in postmenopausal women with advanced breast cancer (ABC). Proc ASCO 2001; Abstract 2025.

Howell A. Preliminary experience with pure antiestrogens. Clin Cancer Res 2001;7:4369s-4375s; discussion 4411s-4412s. Abstract

Howell A et al. Comparison of efficacy and tolerability of fulvestrant (Faslodex) with anastrozole (Arimidex) in postmenopausal women with advanced breast cancer. Breast Cancer Res Treat 2000;64(1): No Link available.

Johnston SR. Fulvestrant (AstraZeneca). Curr Opin Investig Drugs 2002;3(2):305-12. Abstract

Jones S. Fulvestrant (‘Faslodex®’) versus anastrozole (‘Arimidex®’) for the treatment of advanced breast cancer in postmenopausal women – safety update on the combined analysis of two multicenter trials. Breast Cancer Res Treat 2001;Abstract 455.

Mauriac L. Fulvestrant (‘Faslodex®’) is effective in advanced breast cancer in postmenopausal patients with visceral metastases: Comparison with anastrazole. Breast Cancer Res Treat 2001; Abstract 452.

Osborne CK. A double-blind randomized trial comparing the efficacy and tolerability of FaslodexTM (fulvestrant) with ArimidexTM (anastrozole) in postmenopausal (PM) women with advanced breast cancer (ABC). Breast Cancer Res Treat 2000;64(1): No link available.

Osborne CK et al. Selective estrogen receptor modulators: Structure, function and clinical use. J Clin Oncol 2000;18(17):3172-3186. Abstract

Parker LM et al. Greater duration of response in patients receiving fulvestrant (‘Faslodex’) compared with those receiving anastrozole (‘Arimidex’). Proc ASCO 2002;Abstract 160.

Robertson JF. Estrogen receptor downregulators: New antihormonal therapy for advanced breast cancer. Clin Ther 2002;24 Suppl A:A17-30. Abstract

Robertson JFR. A comparison of the single-dose pharmacokinetics (PK) of ‘Faslodex’ (fulvestrant) 250 mg when given as either a one x 5-ml intramuscular (IM) injection or two x 2.5-ml injections in postmenopausal (PM) women with advanced breast cancer (ABC). Breast Cancer Res Treat 2000;No link available.

Rosenberg Z and RS et al. Is ICI 182,780 an antiprogestin in addition to being an antiestrogen? Breast Cancer Res Treat 2000;60:1-8. Abstract

Vergote I. Evidence of continued sensitivity to endocrine agents in postmenopausal women with advanced breast cancer progressing on fulvestrant (‘Faslodex®’) treatment. Breast Cancer Res Treat 2001;Abstract 446.

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George W Sledge, Jr, MD
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Anthony Howell, BSc, MBBS, MSc, FRCP
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I Craig Henderson, MD
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Eleftherios P Mamounas, MD
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