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Home: Oncology Leader Commentary: Richard Margolese, MD

Click on the topic below for comments by Dr Richard Margolese to comment on. You will also find links to related articles and clinical trials.

Surgery and breast cancer
Philosophy of DCIS management
Excision alone for DCIS
DCIS subsets
Margins and DCIS
Is DCIS a surgical disease?
Tamoxifen for DCIS
NSABP DCIS trials
Tamoxifen: Prevention or delay of clinical onset of disease
Risk-benefits of tamoxifen for DCIS
Tamoxifen and venous thrombosis
Duration of preventive effect of tamoxifen
Mortality effects of tamoxifen in high-risk women
Raloxifene as chemoprevention

Philosophy of DCIS management

Interview with Neil Love, MD from Breast Cancer Update for Surgeons, Program 1 2000

Play Audio Below:

We have sort of this cultural approach that DCIS is cancer and we’ve got to do something severe about it. And it brings us to the paradox — as it does with high-risk people — that the prophylaxis, surgically, is a bigger operation than the actual treatment for cancer has become. In the case of DCIS, there’s a certain logical merit to this because while we have statistics that say that invasive cancer is equally curable or equally not curable, depending on mastectomy or conservative surgery, it remains that DCIS can be essentially 100% cured with total mastectomy. Whereas, conserving surgery leaves open the chance that there will be recurrence, that that recurrence will be invasive cancer, and that some people will die of that. I think it’s important to understand that even total mastectomy doesn’t cure 100% of the people. If you need proof for that just look at the entity we call occult breast cancer, where people show up with lymph node metastasis and we don’t see a primary, and they even show up with distant metastasis and we don’t see a primary. So we understand why people with DCIS may die of their disease even though the mastectomy should have cured them. The question is if you do other treatments like breast conserving surgery and radiation, what is the risk of dying? And the answer that we seem to have is, "It’s no greater."

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