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Editor’s Note
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The “Kaplan
Regimen” |
Our Continuing Medical Education (CME) group focuses on emerging
clinical research data and the perspectives of clinical investigators.
We also know that the viewpoints of community-based physicians
are another valuable resource for our work. To that end, we gather
data about decision-making by community-based physicians via national
telephone surveys and editorial working group meetings. Arecent
Breast Cancer Update working group meeting in New York was very
informative. As part of that platform, the 35 participating medical
oncologists submitted four cases from their practices that we evaluated
beforehand, and in some cases, discussed with the working group.
Dr Barry Kaplan, an oncologist from Queens, submitted a particularly
provocative case. This premenopausal woman, in her late 30s, presented
with primary breast cancer and multiple bone metastases. The patient’s
tumor was ER/PR-positive and HER2-positive, and the patient — who
was very well-versed about her prognosis and usual therapeutic
options — pressed Dr Kaplan for the most intense treatment
regimen that would be rational.
After reviewing a variety of options, Dr Kaplan, with strong
support and agreement from the patient, utilized a combination
of docetaxel, capecitabine, an LHRH agonist, anastrozole, trastuzumab,
and a bisphosphonate. Our two faculty members for this part of
the meeting — Drs Hy Muss and Eric Winer — seemed to
blanch at the concluding Powerpoint comment from Dr Kaplan’s
case write-up: “I think this was a good choice for this woman;
do you?” I asked the group, knowing there would be a variety
of responses.
Dr Kaplan, a regular listener of our series, is well-aware that
most research leaders — including Drs Muss and Winer — espouse
a sequential, single-agent approach to the treatment of metastatic
breast cancer. Certainly, this “shotgun” approach of
chemotherapy, endocrine treatment and biologic therapy was very
atypical in Dr Kaplan’s practice. While one might argue that
there is no evidence to support this approach, it is also clear
that a randomized, postprogression, crossover trial of the “Kaplan
Regimen” would encounter significant accrual challenges if
eligibility were restricted to young, premenopausal women with
ER/PR-positive, HER2- positive breast cancer.
This case sparked a lively, although not totally conclusive,
discussion. While it was clear that most attendees would not have
utilized the “Kaplan Regimen,” I found a new appreciation
for the depth and complexity of evidence-based oncology. In that
regard, our CME group developed a new simplified graphical model
for clinical decision-making (Figure 1). For any given situation,
treatments in the “blue” area represent accepted standards
of care based on credible clinical research results. In metastatic
breast cancer, there are the multiple treatment options in this
category, and the light “blue” area depicts the therapy
an individual oncologist might recommend. The treatments in the “red” area
are critical from a CME perspective in that these types of options
are not supported by research evidence, although they might move
into the “blue” area as clinical trial data evolve.
The lead interview in this issue of Breast Cancer Update provides
a perfect example of how this model can be applied. Dr Mark Pegram
comments on adjuvant systemic therapy options for the patient with
ER-negative, HER2-positive breast cancer. Dr Pegram describes his
enthusiasm for the ongoing BCIRG-006 adjuvant trastuzumab trial,
but he clearly believes that the nonprotocol use of adjuvant trastuzumab
should be in the “red” area (Figure 1).
On the other hand, as first-line therapy for patients with ER-negative,
HER2- positive metastatic disease, Dr Pegram believes that trastuzumab
either alone or in combination with chemotherapy are the two main
options in the “blue” area, and he disagrees with the
small number of physicians utilizing chemotherapy without trastuzumab.
While one can argue that palliative situations like metastatic
breast cancer must be managed with empathetic creativity, there
are many effective therapies that can minimize morbidity and prolong
survival. Do you believe the “Kaplan Regimen” has merit
in a nonprotocol setting? Have you ever utilized such a strategy?
Or is it a choice that belongs in the “red zone”? Kindly
email your input on these and any other challenging questions in
your practice to NLove@med.miami.edu.
— Neil Love, MD
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