Interview
with Neil Love, MD from Breast Cancer Update for Medical Oncologists,
Program 4 2000
Play
Audio Below:
Dr.
Loprinzi: Soy phytoestrogens, in our hands, did not show any benefit
whatsoever. We were somewhat surprised. We had been hopeful that
it would have been beneficial, but the actual numbers were worse
in the soy group versus the placebo group, not statistically significantly
so, and also there is actually no evidence in our hands that the
soy preparation we used, which was equivalent to three 8oz glasses
of soy milk per day, that there was any benefit there. Vitamin E,
we did see a bit of benefit, but not very much. It amounted to about
one hot flash reduction per person, per day. So if a person is not
having too much in the way of hot flashes then vitamin E is a reasonable
choice, given that it is readily available, it is inexpensive, it
is virtually non-toxic. In placebo-controlled trials any toxicity
you get is equivalent in the placebo group versus the vitamin E
group, and several good studies have shown that.
Dr.
Love: What’s the dose?
Dr.
Loprinzi: 800 I.U.’s a day is what we utilized in our trial,
and you get the placebo effect plus a little bit more. So that’s
a reasonable thing for people to start off with.
Biopsy
confirmed benign breast disease, postmenopausal use of exogenous
female hormones, and breast carcinoma risk. Byrne,
C.; Connolly, J. L.; Colditz, G. A., and Schnitt, S. J.. Cancer.
89(10):2046-2052, 2000 Nov 15.
Postmenopausal
estrogens - Opposed, unopposed, or none of the above Willett, W. C.; Colditz, G., and Stampfer, M. (Reprint available
from: Willett WC Harvard Univ, Sch Publ Hlth, Dept Nutr 667 Huntington
Ave Boston, MA 02115 USA).. Jama: Journal of the American Medical
Association. 283(4):534-535, 2000 Jan 26. No abstract
Re:
Effect of hormone replacement therapy on breast cancer risk: Estrogen
versus estrogen plus progestin Archer, D. F.; Bush, T., and Nachtigall, L. E. (Reprint available
from: Nachtigall LE NYU, Sch Med, Dept Obstet & Gynecol 251
E 33rd St New York, NY 10016 USA).. Journal of the National Cancer
Institute. 92(23):1950-1951, 2000 Dec 6. No abstract
Estrogen
deficiency: In search of symptom control and sexuality. Loprinzi, C. L. and Barton, D. Journal of the National Cancer
Institute. 92(13):1028-1029, 2000 Jul 5. No abstract
