Incidence
of vasomotor symptoms in breast cancer patients
Interview
with Neil Love, MD from Breast Cancer Update for Medical Oncologists,
Program 4 2000
Play
Audio Below:
Probably
50% of menopausal women who have had breast cancer, have had significant
troubles with menopausal type symptoms, and the vast majority of
that menopausal symptomatology problem is represented by hot flashes.
There are some people that it’s vaginal dryness or dyspareunia,
that stuff, but is mainly hot flashes. And I think it’s a good
50%, especially if you take women who are on tamoxifen versus not.
Now, it will vary with time, and many times these things get better,
but it may take months or years for them to get better.
I
think for actually about half of the postmenopausal women it’s
a substantial problem and maybe people say well, lets make that
25%. We have not had problems putting patients on our trials. We
looked at soy a while ago and we put on, I believe 160 women in
two months on this clinical trial. Which is a wild sort of accrual
that many people would love to have. We had to actually close the
trial much sooner than we had expected. So, there are just oodles
of patients out there. With other agents we’ve put on 50 or
more patients per month on these trials.
Biopsy
confirmed benign breast disease, postmenopausal use of exogenous
female hormones, and breast carcinoma risk. Byrne,
C.; Connolly, J. L.; Colditz, G. A., and Schnitt, S. J.. Cancer.
89(10):2046-2052, 2000 Nov 15.
Postmenopausal
estrogens - Opposed, unopposed, or none of the above Willett, W. C.; Colditz, G., and Stampfer, M. (Reprint available
from: Willett WC Harvard Univ, Sch Publ Hlth, Dept Nutr 667 Huntington
Ave Boston, MA 02115 USA).. Jama: Journal of the American Medical
Association. 283(4):534-535, 2000 Jan 26. No abstract
Re:
Effect of hormone replacement therapy on breast cancer risk: Estrogen
versus estrogen plus progestin Archer, D. F.; Bush, T., and Nachtigall, L. E. (Reprint available
from: Nachtigall LE NYU, Sch Med, Dept Obstet & Gynecol 251
E 33rd St New York, NY 10016 USA).. Journal of the National Cancer
Institute. 92(23):1950-1951, 2000 Dec 6. No abstract
Estrogen
deficiency: In search of symptom control and sexuality. Loprinzi, C. L. and Barton, D. Journal of the National Cancer
Institute. 92(13):1028-1029, 2000 Jul 5. No abstract
