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Home: Oncology Leader Commentary: Craig Hederson, MD

Click on the topic below for comments by Dr Craig Henderson to comment on. You will also find links to related articles and clinical trials.

Historical perspective on adjuvant endocrine therapy
More recent trials of adjuvant ovarian ablation
Intergroup trial of adjuvant endocrine therapy
Is tamoxifen more effective in a low estrogen environment
Zoladex plus tamoxifen as adjuvant therapy
Choosing a method of ovarian ablation
Age and menopausal status
Adjuvant chemotherapy and the ovaries
Emotional issues in decision-making
Combining tamoxifen and an aromatase inhibitor in postmenopausal women
Taxanes as adjuvant therapy
Nodal status and choice of adjuvant systemic therapy
Timing of radiation therapy with AC-Taxol
Dose of adjuvant chemotherapy
Liposomal delivery of cytotoxics


Choosing a method of ovarian ablation

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 2 2000

Play Audio Below:

Surgical oophorectomy has an advantage of being fairly quick and relatively easily done these days. On the other hand, a large percentage of people have an aversion to surgery in general, to loosing another organ, – the feeling "I can change my mind". You can obviously start with a LHRH agonist and then you can make a switch at a later time. And it gives us the kind of flexibility that we just haven’t had in the past. A flexibility even to start one way, as I said, and then make a decision: "Well, I’m going to go to surgical therapy later." For example, you might even go for the five years and at the end of the time, have an oophorectomy rather than continuing, say, beyond five years.

Relevant Articles:

Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: A randomized study.
Klijn, J. G. M.; Beex LVAM; Mauriac, L.; van Zijl, J. A.; Veyret, C.; Wildiers, J.; Jassem, J. Piccart, M.; Burghouts, J.; Becquart, D.; Seynaeve, C.; Mignolet, F., and Duchateau, L. (Reprint available from: Klijn JGM Dr Daniel den Hoed Klin, Rotterdam Canc Inst, Dept Med Oncol Groene Hilledijk 301 NL-3075 EA Rotterdam Netherlands). Journal of the National Cancer Institute. 92(11):903-911, 2000 Jun 7.

Prevention of rat mammary carcinoma utilizing leuprolide as an equivalent to oophorectomy.
Jett, E. A.; Lerner, M. R.; Lightfoot, S. A.; Hanas, J. S.; Brackett, D. J., and Hollingsworth, A. B. (Reprint available from: Hollingsworth AB Mercy Hosp, Womens Ctr 4300 McAuley Blvd Oklahoma City, OK 73120 USA). Breast Cancer Research & Treatment. 58(2):131-136, 1999 Nov.

Combined endocrine therapy for breast cancer - New life for an old idea?
Davidson, N. E. (Reprint available from: Davidson NE Johns Hopkins Oncol Ctr 1650 Orleans St,Rm 409 Baltimore, MD 21231 USA). Journal of the National Cancer Institute 92(11):859-860, 2000 Jun 7. No abstract

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