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Trastuzumab: 2002 San Antonio Breast Cancer Symposium update

Carey LA et al. Response to trastuzumab (Herceptin) given with paclitaxel (taxol, T) immediately following 4AC as initial therapy for primary breast cancer (BrCa). Breast Cancer Res Treat 2002; Abstract 424.

Chan A et al. Clinical efficacy & toxicity of Herceptin in metastatic breast cancer patients with tumours that overexpress Her-2 neu: The Australian expanded access program. Breast Cancer Res Treat 2002; Abstract 444.

Chan A et al. Multinational phase II study of navelbine (N) and herceptin (H) as first-line therapy for HER2-overexpressing metastatic breast cancer (HER2+ MBC). Breast Cancer Res Treat 2002; Abstract 434.

Dieras V et al. Previous cumulative anthracycline dose is the main determinant of LVEF decrease in breast cancer patients treated with trastuzumab (Herceptin®): Results of a French compassionate use program. Breast Cancer Res Treat 2002; Abstract 425.

Filipovich E et al. Chemotherapy with trastuzumab plus vinorelbine in patients with erb-B2 overexpressed tumor is active in metastatic breast cancer. Breast Cancer Res Treat 2002; Abstract 436.

Gelmon K et al. Efficacy and safety of Herceptin in women with Her2-positive (HER2+) metastatic breast cancer (MBC) who have progressed on a prior herceptin-containing regimen. Breast Cancer Res Treat 2002; Abstract 440.

Janku F et al. Weekly trastuzumab (T) and paclitaxel (P) in metastatic breast cancer (MBC). The impact of taxane free interval (TFI) on treatment outcomes. Breast Cancer Res Treat 2002; Abstract 435.

Lüftner DI et al. Evaluation of serum HER-2/neu for outcome assessment and monitoring of Herceptin plus combination chemotherapy in metastatic breast cancer. Breast Cancer Res Treat 2002; Abstract 427.

Lüftner DI et al. Longitudinal HER-2/neu measurements during treatment with Herceptin, epirubicin plus cyclophosphamide (HEC): Interim serum results of a phase II study in patients with metastatic breast cancer. Breast Cancer Res Treat 2002; Abstract 423.

Miller KD et al. Phase II study of gemcitabine, paclitaxel and trastuzumab in metastatic breast cancer: A Hoosier Oncology Group trial. Breast Cancer Res Treat 2002; Abstract 437.

Pichon MF et al. Serum HER-2/neu extracellular domain parallels responses to trastuzumab treatment of recurrent breast cancer. Breast Cancer Res Treat 2002; Abstract 426.

Raab G et al. Multicenter randomized phase II study of docetaxel (Doc) given q3w vs q1w plus trastuzumab (Tra) as first line therapy for HER2 overexpressing adjuvant anthracyclin pretreated metastatic breast cancer (MBC). Breast Cancer Res Treat 2002; Abstract 443.

Robert N et al. Phase III comparative study of trastuzumab and paclitaxel with and without carboplatin in patients with HER-2/neu positive advanced breast cancer. Breast Cancer Res Treat 2002; Abstract 35.

Thomssen CH et al. Cardiac safety of epirubicin/cyclophosphamide (EC) alone and in combination with herceptin in women with metastatic breast cancer (MBC). Breast Cancer Res Treat 2002; Abstract 430.

Van Pelt AE et al. Phase II study of neoadjuvant trastuzumab plus docetaxel for locally advanced and metastatic breast cancer that overexpresses HER2/neu: A preliminary report. Breast Cancer Res Treat 2002; Abstract 441.

Yardley DA et al. Final results of the Minnie Pearl Cancer Research Network first-line trial of weekly paclitaxel/carboplatin/trastuzumab in metastatic breast cancer. Breast Cancer Res Treat 2002; Abstract 439.

Clinical trials involving the combination of vinorelbine and capecitabine

Ahn Sr, JH et al. Phase II study of combination chemotherapy of capecitabine and vinorelbine in metastatic breast cancer with previous exposure to anthracycline and taxane: Preliminary results. Proc ASCO 2002; Abstract 2030.

Domenech G et al. Vinorelbine/capecitabine (VINOCAP) combination remission induction therapy for metastatic breast cancer (MBC). Proc ASCO 2001; Abstract 1939.

Ghosn M et al. Vinorelbine (Navelbine) IV and capecitabine (vinocap) as front line chemotherapy in metastatic breast cancer (MBC). Proc ASCO 2002; Abstract 1978.

Hess DD et al. Phase I-II trial of capecitabine and vinorelbine in elderly patients (pts: > 65y) with metastatic breast cancer (MBC): SAKK 25/99 for the Swiss Group of Clinical Cancer Research, Berne, Switzerland. Proc ASCO 2002; Abstract 2915.

Schott AF et al. Vinorelbine (VR) and capecitabine (CAP) in metastatic breast cancer: Phase I/II study with correlative genotype, phenotype, and pharmacokinetics. Breast Cancer Res Treat 2002; Abstract 338.

Von Minckwitz G et al. In-vivo-chemosensitivity adapted preoperative chemotherapy (PCT) in patients (P) with primary operable breast cancer. First experiences of the pilot GEPARTRIO - study. Breast Cancer Res Treat 2002; Abstract 156.

Welt A et al. Phase I study of capecitabine and vinorelbine in pretreated patients with metastatic breast cancer. Proc ASCO 2001; Abstract 1979.

Welt A et al. Extended phase I study of capecitabine in combination with vinorelbine in pretreated patients with metastatic breast cancer. Breast Cancer Res Treat 2002; Abstract 336.

 

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Michael Baum, ChM, FRCS
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Peter Ravdin, MD, PhD
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Charles L Vogel, MD, FACP
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Marc L Citron, MD
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