Endocrine
therapy versus cytotoxic therapy of metastatic disease
Interview
with Neil Love, MD from Breast Cancer Update for Medical Oncologists,
Program 5 2000
Play
Audio Below:
I
think the data there is very straightforward. If you have a liver
met, and it’s estrogen receptor positive, it is going to respond
like a metastasis anywhere else. So, if the patient does not have
rapidly progressive liver disease, I’m quite comfortable giving
that patient hormonal manipulation as their initial therapy. It’s
likely to be just as effective as any chemotherapeutic agent. It’s
likely to give the patient a longer progression-free survival. It’s
likely to give the patient better quality of life. So, if one suspects
that the tempo of the disease is a relatively gradual one, why not
start with a hormonal manipulation.
Relevant
Links:
Low-dose
oral fluorouracil with eniluracil as first-line chemotherapy against
advanced breast cancer: A phase II study. Smith,
I. E.; Johnston, S. R. D.; O'Brien, M. E. R.; Hickish, T. F.; de
Boer, R. H.; Norton, A.; Cirkel, D. T., and Barton, C. M.. Journal
of Clinical Oncology. 18(12):2378-2384, 2000 Jun.
Comparison
of chemotherapy with chemohormonal therapy as first-line therapy-for
metastatic, hormone-sensitive breast cancer: An Eastern Cooperative
Oncology Group study. Sledge,
G. W.; Hu, P.; Falkson, G.; Tormey, D., and Abeloff, M.. Journal
of Clinical Oncology. 18(2):262-266, 2000 Jan.
Assessment
of the need for palliative care as perceived by individual cancer
patients and their families - A review of instruments for improving
patient participation in palliative care [Review]. Osse,
B. H. P.; Vernooij-Dassen MJFJ; de Vree, B. P. W.; Schade, E.,
and Grol RPTM. Cancer. 88(4):900-911, 2000 Feb 15.
Anastrozole
is superior to tamoxifen as first-line therapy for advanced breast
cancer in postmenopausal women: Results of a North American multicenter
randomized trial. Nabholtz,
J. M.; Buzdar, A.; Pollak, M.; Harwin, W.; Burton, G.; Mangalik,
A.; Steinberg, M.; Webster, A., and von Euler, M. Journal of Clinical
Oncology. 18(22):3758-3767, 2000 Nov 15.
The
role of tumour markers in improving the accuracy of conventional
chest X-ray and liver echography in the post-operative detection
of thoracic and liver metastases from breast cancer. Nicolini,
A.; Carpi, A.; Ferrari, P.; Anselmi, L.; Spinelli, C.; Conte, M.,
and Miccoli, P. (Reprint available from: Nicolini A Univ Pisa, Dept
Internal Med Pisa Italy).. British Journal of Cancer. 83(11):1412-1417,
2000 Dec. In process
Minimal
solid tumor involvement of regional and distant sites - When is
a metastasis not a metastasis?
Page,
D. L.; Anderson, T. J., and Carter, B. A. (Reprint available from:
Page DL
Vanderbilt Univ, Med Ctr, Dept Pathol C3311 Med Ctr N,1161 21st
Ave S Nashville, TN 37232 USA). Cancer. 86(12):2589-2592, 1999 Dec
15. No abstract
Radiation
therapy in the management of brain metastases from breast cancer.
Breast Cancer Research & Treatment. Fokstuen, T.; Wilking, N.; Rutqvist, L. E.; Wolke, J.; Liedberg,
A.; Signomklao, T., and Fernberg, J. O. (Reprint available from:
Fokstuen T Karolinska Hosp, Radiumhemmet, Dept Oncol S-17176 Stockholm
Sweden).. 62(3):211-216, 2000 Aug. In progress
Stereotactic
radiosurgery for brain metastases from breast cancer. Firlik, K. S.; Kondziolka, D.; Flickinger, J. C., and Lunsford,
L. D. Annals of Surgical Oncology. 7(5):333-338, 2000 Jun. In
progress
