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Home: Oncology Leader Commentary: Aman Buzdar, MD

Click on the topic below for comments by Dr Aman Buzdar to comment on. You will also find links to related articles and clinical trials.

Arimidex as first-line therapy
Toxicity profile of Arimidex
Choice of first-line endocrine therapy for postmenopausal patients
Neoadjuvant anastrozole
ATAC adjuvant trial: Arimidex vs Tamoxifen vs the Combination
Adjuvant tamoxifen in low-risk patients
Adjuvant tamoxifen in premenopausal patients
Adjuvant tamoxifen in patients with DCIS

Adjuvant tamoxifen in low-risk patients

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 1 2000

Play Audio Below:

There is no question that if we are giving tamoxifen to a high-risk woman who has no concern – and here is a woman that has, let’s say, T1 ER-positive tumor – there is no question that you have two potential benefits. One is that whatever the small risk is there, that will be reduced by half, and the risk of contralateral or ipsilateral new primary will be also reduced by 50%. So, I sit down and discuss these options very carefully with the woman who has relatively small primary – which few years ago we would not consider anything because the risk benefit ratio looked close to one. But now with this major decrease in the second primary, I think then the risk benefit ratio is more in the favor of the patient.

Relevant Articles:

Tamoxifen adjuvant treatment duration in early breast cancer: Initial results of a randomized study comparing short-term treatment with long-term treatment. Delozier, T.; Spielmann, M.; Mace-Lesec'h, J.; Janvier, M.; Hill, C.; Asselain, B.; Julien, J. P.; Weber, B.; Mauriac, L.; Petit, J. C.; Kerbrat, P.; Malhaire, J. P.; Vennin, P.; Leduc, B., and Namer, M.. Journal of Clinical Oncology. 18(20):3507-3512, 2000 Oct 15.

Relevant Clinical Trials:

Phase III Study of Prolonged Adjuvant Tamoxifen for Curatively Treated Breast Cancer

Phase III Randomized Adjuvant Study of Tamoxifen in Women with Early Breast Cancer

Study of Tamoxifen in the Prevention of Skeletal and Cardiovascular Morbidity of Adjuvant Chemotherapy in Premenopausal Women With Stage I or II Breast Cancer

Phase III Randomized Study of Wide Local Excision Alone Versus Wide Local Excision Followed by Radiotherapy With or Without Tamoxifen Versus Wide Local Excision Plus Tamoxifen in Patients With Stage I Breast Cancer

Phase III Randomized Study of Adjuvant Clodronate With or Without Systemic Chemotherapy and/or Tamoxifen in Women With Early-Stage Breast Cancer

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Aman Buzdar, MD

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