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Is there a survival benefit to screening mammography
and what is the optimal screening and diagnostic algorithm?
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OVERVIEW:
For years, mammography has been widely accepted as
the gold standard for breast cancer screening. The main
controversies surrounding mammography have been issues
such as what age to begin screening or what type of
mammography is best (screen-film versus digital), rather
than whether or not to screen women. Indeed, the largest
open breast cancer screening clinical research trial
in the United States today compares the screening and
diagnostic value of digital mammography to screen-film
mammography. In 2000, a Cochrane review challenged the
value of screening mammography stating there was no
reliable evidence that breast cancer screening reduced
mortality. Other imaging modalities, such as ultrasonography
and MRI, are being considered for screening. At this
time, however, they are utilized only in specific patient
populations or clinical trials.
In addition to screening controversies, there are
numerous questions about the most effective way to biopsy
a suspicious lesion. Once a breast abnormality is discovered,
numerous diagnostic modalities exist including, but
not limited to: diagnostic mammography, ultrasound,
MRI, fine needle aspiration, Mammotome, core biopsy,
needle localization and surgical excision. Image-guided
interventional procedures offer high accuracy for the
diagnosis of nonpalpable suspicious lesions, generally
without any lasting post-procedure changes on follow-up
mammography.
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Do you believe that
screening mammography significantly lowers the chance of dying from
breast cancer?
Do you believe that screening mammography
significantly lowers the chance of requiring mastectomy to treat
breast cancer?
Which biopsy technique(s) are used most
often for palpable breast masses suspected to be cancer?
14 gauge core needle biopsy
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40% |
Fine needle aspiration
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30% |
11 gauge core needle biopsy
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20% |
16 gauge core needle biopsy
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10% |
Which biopsy technique(s) are most commonly
used for nonpalpable microcalcifications that are negative on ultrasound?
Single wire localization and biopsy
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45% |
Stereotactic percutaneous core needle biopsy
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40% |
Bracketed wire localization and biopsy
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20% |
Stereotactic percutaneous fine needle aspiration
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5% |
Which biopsy techniques
are most commonly used for a nonpalpable mass that on ultrasound
is identified to be a solid lesion?
Wire localization and biopsy
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35% |
Stereotactic percutaneous core needle biopsy
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25% |
Ultrasonic percutaneous core needle biopsy
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20% |
Ultrasonic percutaneous fine needle aspiration
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15% |
Stereotactic percutaneous fine needle aspiration
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5% |
THE SCREENING MAMMOGRAPHY DEBATE
There is no evidence that clinical examination, breast ultra sonography,
or teaching self examination of the breast are effective tools for
early detection. However, randomised controlled trials have shown
that screening by mammography can significantly reduce mortality
from breast cancer by up to 40% in those who attend. The benefit
is greatest in women aged 50-70 years. Published data from the combined
Swedish trials showed an overall reduction in breast cancer mortality
of 29% during 12 years of follow up in women aged over 50 who were
invited for screening.
Blamey RW et al. BMJ 2000;321(7262):689-93.
Full
Text
In 2000, we re p o rted that there is no reliable evidence that
scre e n i n g for breast cancer reduces mortality. As we discuss
here, a Cochrane review has now confirmed and strengthened our previous
findings. The review also shows that breast-cancer mortality is
a misleading outcome measure. Finally, we use data supplemental
to those in the Cochra n e review to show that screening leads to
more aggressive treatment . . . We have provided detailed evidence
on the mammography screening trials, and hope that women, clinicians,
and policy-makers will consider these findings carefully when they
decide whether or not to attend or support screening programmes.
Any hope or claim that screening mammography with more modern technologies
than applied in these trials will reduce mortality without causing
too much harm will have to be tested in large, well-conducted randomised
trials with all-cause mortality as the primary outcome.
Olsen O, Gøtzsche
PC. Lancet 2001;358(9290):1340-2.
Abstract
Sir Ole Olsen and Peter Gøtzsches full report ...
is riddled with misrepresentation, inconsistency in the treatment
of the randomised trials, and errors of method and fact...
The [report does] not inspire confidence in Olsen and Gøtzsches
judgment of study quality or for the notion that all-cause mortality
is an appropriate endpoint. As if deaths from road-traffic accidents
or hip fractures were in some way indicative of the effect of breast-cancer
screening. We believe that Olsen and Gøtzsche referring readers
to a website for details of why they were right all along, is a
clever and convenient way of subverting the peer review process
and shielding their work from proper scientific scrutiny. The full
report is not the official Cochrane review, despite its misleading
title. Olsen and Gøtzsches review is of poor quality,
and, therefore, unreliable. Given this poor quality, Hortons
uncritical commentary is at best ill considered. Nothing in the
report or commentary disproves the finding of millions of person-years
of experimental research, and dozens of previous expert reviews,
that mammographic screening significantly reduces mortality from
breast cancer.
Duffy SW et al. Lancet.
2001;358(9299):2166.
ULTRASOUND AND MRI FOR SCREENING
Ultrasonography and magnetic resonance (MR) tomography are helpful
tools to evaluate unclear lesions found at screening mammography.
Ultrasound is particularly useful to prove the presence of a cyst
or to further examine unclear, asymmetrical densities. With MR mammography,
carcinomas can be found even when x-ray mammography or ultrasonography
are limited due to diffuse, benign, proliferative changes. Ultrasound
guidance has greatly facilitated core needle biopsy for suspicious
lesions. Additionally, approved devices for MR-guided biopsy are
commercially available. As a primary screening tool, ultrasound
or MR mammography may be used only in women who are positive for
BRCA-1 or BRCA-2 mutations or who are otherwise at high risk for
breast cancer.
Delorme S. Radiologe 2001;41(4):371-8.
Abstract
RADIOLOGICAL INTERVENTIONAL PROCEDURES
Radiological interventional procedures on the breast are still
work in progress. Initiation of percutaneous macrobiopsy techniques
such as stereotactic or ultrasound-guided core biopsy, mammotomy
or Abbi Site-Select procedures allows the physician to expect a
high accuracy for the diagnosis of non palpable suspected breast
abnormalities, thus eliminating the need for at least half of the
surgical biopsies done for this indication. Furthermore, the absence
of any lasting post-procedural changes on follow-up mammography
contrasts with the scarring associated with traditional surgical
open biopsy and obviates confusion in subsequent mammographic interpretation.
Recently, development of percutaneous radiofrequency or cryotherapy
ablation of breast cancer has been related. All these cost-saving
procedures lead to medical and potential medical legal pitfalls.
Marcy PY et al. Bulletin
du Cancer 2001;88(12): 1159-1166.
Abstract
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ACRIN-6652: SCREENING AND DIAGNOSTIC STUDY
OF DIGITAL MAMMOGRAPHY VERSUS SCREEN-FILM MAMMOGRAPHY
IN THE DETECTION OF BREAST CANCER IN WOMEN OPEN
PROTOCOL |
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PROJECTED ACCRUAL: 49,500
patients |
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Protocol: All patients undergo
a two-view digital and a two-view screen-film mammography
of each breast. Quality of life assessments are performed
in the first 800 patients before mammography screening and
1200 (600 with positive screening results and 600 with negative
screening results) after screening.
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STUDY CONTACT
Etta Pisano, Chair
Phone: 919-966-6957
American College of Radiology Imaging Network
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UPCC-ACR-6884: SCREENING AND DIAGNOSTIC
STUDY OF MAGNETIC RESONANCE IMAGING IN WOMEN WITH SUSPECTED
BREAST CANCER OPEN
PROTOCOL |
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PROJECTED ACCRUAL: 420
patients |
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Protocol: Physical exam, two-view
screening mammogram and MRI with gadolinium contrast. All suspicious
lesions undergo a core needle or excisional biopsy. |
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STUDY CONTACT
Mitchell Schnall, Chair
Phone: 215-662-7238
University of Pennsylvania Cancer Center
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COCHRANE
REVIEW: ALL-CAUSE MORTALITY IN MEDIUM-QUALITY SCREENING TRIALS
AFTER 13 YEARS. |
Study |
Screened
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Not Screened
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Relative Risk*
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# of Deaths
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# of Women
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# of Deaths
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# of Women
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(95% CI)
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Malmö 1976 |
2537
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21088
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2593
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21195
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0.98
(0.93-1.04)
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Canada 1980a |
418
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25214
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414
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25216
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1.01
(0.88-1.16)
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Canada 1980b |
734
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19711
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690
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19694
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1.06
(0.96-1.18)
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Subtotal |
3689
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66013
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3697
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66105
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1.00
(0.96-1.05)
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*Fixed effects model
Adapted from Olsen O, Gøtzsche PC. Lancet 2001;358(9290):1284-5
Abstract
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View References
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