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Source
Journal of Clinical Oncology 2005;23(10):2155-61. Abstract
Purpose
- Evaluate efficacy and tolerability of capecitabine in older women with ABC
Patients and methods
- 73 patients (median age: 73 years old)
- 30 patients received oral capecitabine 1,250 mg/m2 BID on days one to 14
every 21 days
– Due to two toxic deaths, capecitabine 1,000 mg/m2 BID was
administered to the remaining 43 patients
Results
- Dose reductions were required in 30 percent of patients in the standard dose
group, but capecitabine was given without a dose reduction to 95% of
patients in the low-dose group.
- Capecitabine had a favorable safety profile.
– Grade III/IV toxicities: ≤10 percent fatigue, diarrhea, dyspnea and nausea
- Efficacy
– 1,250 mg/m2 BID: response rate was 36.7 percent; 33 percent had disease
stabilization at ≥24 weeks.
– 1,000 mg/m2: response rate was 34.9 percent; 46 percent had prolonged
disease stabilization.
– Median time to disease progression was four months in both groups.
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