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Home: Recent Publications: Recent Publications 2000

Miscellaneous Topics l Antiestrogens, Tamoxifen l Aromatase Inhibitors
Faslodex®
(Fulvestrant, ICI182180) lOvarian Ablation/Suppression
Estrogen/Progesterone Receptors


Miscellaneous articles

Static disease on anastrozole provides similar benefit as objective response in patients with advanced breast cancer.
Robertson, J. F. R.; Howell, A.; Buzdar, A.; von Euler, M., and Lee, D.. Breast Cancer Research & Treatment. 58(2):157-162, 1999 Nov.

Eye problems in breast cancer patients treated with tamoxifen.
Breast Cancer Research & Treatment. 60(2):167-172, 2000 Mar.

Symptoms associated with oophorectomy and tamoxifen treatment fo breast cancer in premenopausal Vietnamese women.
Love, R. R.; Duc, N. B.; Binh, N. C.; Van Dinh, N., and Havighurst, T. C. (Reprint available from: Love RR Univ Wisconsin, Ctr Comprehens Canc Madison, WI 53706 USA). Breast Cancer Research & Treatment. 58(3):281-286, 1999 Dec.

Endocrine therapies for patients with recurrent breast cancer: Predictive factors for responses to first- and second-line endocrine therapies.
Kurebayashi, J.; Sonoo, H.; Inaji, H.; Nishimura, R.; Iino, Y.; Toi, M.; Kobayashi, S., and Saeki, T. (Reprint available from: Kurebayashi J Kawasaki Med Sch, Dept Breast & Thyroid Surg 577 Matsushima Okayama 7010192 Japan).. Oncology. 59(Suppl 1):31-37, 2000.

Influence of estrogen receptor variants on the determination of ER status in human breast cancer.
Huang, A. H.; Leygue, E.; Dotzlaw, H.; Murphy, L. C., and Watson, P. H. (Reprint available from: Watson PH Univ Manitoba, Dept Pathol Winnipeg MB R3T 2N2 Canada). Breast Cancer Research & Treatment. 58(3):219-225, 1999 Dec.

The pure antiestrogen ICI 182780 is more effective in the induction of apoptosis and down regulation of BCL-2 than tamoxifen in MCF-7 cells.
Diel, P.; Smolnikar, K., and Michna, H. (Reprint available from: Diel P DSHS Cologne, Dept Morphol & Tumor Res Carl Diemer Weg 6 D-50927 Cologne Germany).. Breast Cancer Research & Treatment. 58(2):87-97, 1999 Nov.

Cyclophosphamide, methotrexate, and fluorouracil versus tamoxifen plus ovarian suppression as adjuvant treatment of estrogen receptor-positive pre-/perimenopausal breast cancer patients: Results of the Italian Breast Cancer Adjuvant Study Group 02 Randomized Trial.
Boccardo, F.; Rubagotti, A.; Amoroso, D.; Mesiti, M.; Romeo, D.; Sismondi, P.; Giai, M.; Genta, F.; Pacini, P.; Distante, V.; Bolognesi, A.; Aldrighetii, D., and Farris, A. Journal of Clinical Oncology. 18(14):2718-2727, 2000 Jul.

The excess burden of breast carcinoma in minority and medically underserved communities - Application, research, and redressing institutional racism
Shinagawa, S. M.. Cancer. 88(5 Suppl S):1217-1223, 2000 Mar 1.

Phytoestrogens and adjuvant endocrine treatment of breast cancer.
This, P. and Magdelenat, H.. Journal of Clinical Oncology. 18(14):2792, 2000 Jul. No abstract

Oestrogen and growth factor cross-talk and endocrine insensitivity and acquired resistance in breast cancer [Review].
Nicholson, R. I. and Gee, J. M. W. (Reprint available from: Nicholson RI Univ Wales, Coll Med, Tenovus Canc Res Ctr Cardiff CF14 4XX S Glam Wales). British Journal of Cancer. 82(3):501-513, 2000 Feb. No abstract

Safety and tolerability of endocrine therapies used in the treatment of advanced breast cancer. Bland, K. I. and Buzdar, A. U. Annals of Surgical Oncology. 6(8 Suppl S) 12S-13S, 1999 Dec. NO ABSTRACT

Future directions in endocrine treatment of advanced breast cancer.
Annals of Surgical Oncology. 6(8 Suppl S):14S-16S, 1999 Dec. NO ABSTRACT

Current status of endocrine therapy for advanced breast cancer.
Annals of Surgical Oncology. 6(8 Suppl S):4S-7S, 1999 Dec. NO ABSTRACT

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Antiestrogens, tamoxifen

Selective estrogen receptor modulators: Structure, function, and clinical use [Review].
Osborne, C. K. and Fuqua, S. A. W. Journal of Clinical Oncology. 18(17):3172-3186, 2000 Sep.

Differences in immunoreactivity of estrogen receptor (ER) in tamoxifen-sensitiveand -resistant breast carcinomas: preclinical and first clinical investigations.
Naundorf, H.; Jost-Reuhl, B.; Becker, M.; Reuhl, T.; Neumann, C., and Fichtner, I. (Reprint available from: Fichtner I Max Delbruck Ctr Mol Med Robert Rossle Str 10 D-13125 Berlin Germany).. Breast Cancer Research & Treatment. 60(1):81-92, 2000 Mar.

Development and characterization of a tamoxifen resistant breast carcinoma xenograft.
Naundorf, H.; Becker, M.; Lykkesfeldt, A. E.; Elbe, B.; Neumann, C.; Buttner, B., and Fichtner, I (Reprint available from: Fichtner I Max Delbruck Ctr Mol Med Robert Rossle Str 10 D-13092 Berlin Germany).. British Journal of Cancer. 82(11):1844-1850, 2000 Jun.

Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: A randomized study.
Klijn, J. G. M.; Beex LVAM; Mauriac, L.; van Zijl, J. A.; Veyret, C.; Wildiers, J.; Jassem, J.; Piccart, M.; Burghouts, J.; Becquart, D.; Seynaeve, C.; Mignolet, F., and Duchateau, L. (Reprint available from: Klijn JGM Dr Daniel den Hoed Klin, Rotterdam Canc Inst, Dept Med Oncol Groene Hilledijk 301 NL-3075 EA Rotterdam Netherlands). Journal of the National Cancer Institute. 92(11):903-911, 2000 Jun 7.

Effects of high dose raloxifene in selected patients with advanced breast carcinoma.
Gradishar, W.; Glusman, J.; Lu, Y.; Vogel, C.; Cohen, F. J., and Sledge, G. W. Cancer. 88(9):2047-2053, 2000 May 1.

Effects of adjuvant tamoxifen on the endometrium in postmenopausal women with breast cancer: A prospective long-term study using transvaginal ultrasound.
Gerber, B.; Krause, A.; Muller, H.; Reimer, T.; Kulz, T.; Makovitzky, J.; Kundt, G., and Friese, K. Journal of Clinical Oncology. 18(20):3464-3470, 2000 Oct 15.

Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels.
Ferno, M.; Stal, O.; Baldetrop, B.; Hatschek, T.; Kallstrom, A. C.; Malmstrom, P.; Nordenskjold, B., and Ryden, S.. Breast Cancer Research & Treatment. 59(1):69-76, 2000 Jan.

Tamoxifen adjuvant treatment duration in early breast cancer: Initial results of a randomized study comparing short-term treatment with long-term treatment.
Delozier, T.; Spielmann, M.; Mace-Lesec'h, J.; Janvier, M.; Hill, C.; Asselain, B.; Julien, J. P.; Weber, B.; Mauriac, L.; Petit, J. C.; Kerbrat, P.; Malhaire, J. P.; Vennin, P.; Leduc, B., and Namer, M.. Journal of Clinical Oncology. 18(20):3507-3512, 2000 Oct 15.

Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women.
Daidone, M. G.; Luisi, A.; Martelli, G.; Benini, E.; Veneroni, S.; Tomasic, G.; De Palo G, and Silvestrini, R. (Reprint available from: Daidone MG Ist Nazl Studio & Cura Tumori Via Venezian 1 I-20133 Milan Italy). British Journal of Cancer. 82(2):270-277, 2000 Jan.

Effect of adjuvant tamoxifen on the endometrium in women with breast cancer: A prospective study using office endometrial biopsy.
Barakat, R. R.; Gilewski, T. A.; Almadrones, L.; Saigo, P. E.; Venkatraman, E.; Hudis, C., and Hoskins, W. J. Journal of Clinical Oncology. 18(20):3459-3463, 2000 Oct 15.

Surveillance for uterine abnormalities in tamoxifen-treated breast carcinoma survivors - A community-based study.
Althuis, M. D.; Sexton, M.; Langenberg, P.; Bush, T. L.; Tkaczuk, K.; Magaziner, J., and Khoo, L. Cancer. 89(4):800-810, 2000 Aug 15.

Similarities and distinctions in the mode of action of different classes of antioestrogens [Review].
Wakeling, A. E. Endocrine-Related Cancer. 7(1):17-28, 2000 Mar.

Approaches targeted to estrogen receptors for treatment of tamoxifen-resistant breast cancer: A brief overview.
Terakawa, N. (Reprint available from: Terakawa N Tottori Univ, Sch Med, Dept Obstet & Gynecol Yonago Tottori 683 Japan).. Oncology. 59(Suppl 1):3-4, 2000. No abstract

Preliminary assessment of cognitive function in breast cancer patients treated with tamoxifen.
Paganini-Hill, A. and Clark, L. J. Breast Cancer Res.earch & Treatment. 64(2):165-176, 2000 Nov.

Symposium overview: Estrogens and antiestrogens in managing the patient with breast cancer.
Newman, L. A.; Wood, W. C.; Sellin, R. V.; Morrow, M.; Vogel, C., and Singletary, S. E. (Reprint available from: Singletary SE Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol 1515 Holcombe Blvd,Box 106 Houston, TX 77030 USA).. Annals of Surgical Oncology. 7(8):568-574, 2000 Sep.

The ovary: cysts, screening, and tamoxifen.
Mourits, M. J. E.; van der Zee, A. G. J.; Willemse, P. H. B., and de Vries, E. G. E. (Reprint available from: de Vries EGE Univ Groningen Hosp, Dept Med Oncol POB 30 001 NL-9700 RB Groningen Netherlands). Lancet. 355(9220):2078-2079, 2000 Jun 10.

Concentrations of tamoxifen and its major metabolites in hormone
responsive and resistant breast tumours.
MacCallum, J.; Cummings, J.; Dixon, J. M., and Miller, W. R. (Reprint available from: MacCallum J Napier Univ, Dept Life Sci Merchiston Campus,Colinton Rd Edinburgh EH10 5DT Midlothian Scotland).. British Journal of Cancer. 82(10):1629-1635, 2000 May.

How is tamoxifen's action subverted?
Jordan, V. C. (Reprint available from: Jordan VC Northwestern Univ, Sch Med, Rober H Lurie Comprehens Canc Ctr 303 E Chicago Ave,Olson Pavil 8258 Chicago, IL 60611 USA). Journal of the National Cancer Institute. 92(2):92-94, 2000 Jan 19. No abstract

Serum lipid levels during and after adjuvant toremifene or tamoxifen therapy for breast cancer.
Joensuu, H.; Holli, K.; Oksanen, H., and Valavaara, R. (Reprint available from: Joensuu H Univ Helsinki, Cent Hosp, Dept Oncol Haartmaninkatu 4,POB 180 FIN-00029 Helsinki Finland). Breast Cancer Research & Treatment. 63(3):225-234, 2000 Oct.

One step forward or one step back with tamoxifen?
Gelmon, K. (Reprint available from: Gelmon K British Columbia Canc Agcy Vancouver BC V5Z 4E6 Canada). Lancet. 356(9233):868-869, 2000 Sep 9. No abstract

Endometrial protection from tamoxifen-stimulated changes by a evonorgestrel-releasing intrauterine system: a randomised controlled trial.
Gardner, F. J. E.; Konje, J. C.; Abrams, K. R.; Brown, L. J. R.; Khanna, S.; Al-Azzawi, F.; Bell, S. C., and Taylor, D. J.. Lancet. 356(9243):1711-1717, 2000 Nov 18.

Combined endocrine therapy for breast cancer - New life for an old idea?
Davidson, N. E. (Reprint available from: Davidson NE Johns Hopkins Oncol Ctr 1650 Orleans St, Rm 409 Baltimore, MD 21231 USA). Journal of the National Cancer Institute. 92(11):859-860, 2000 Jun 7. No abstract

Risk and prognosis of endometrial cancer after tamoxifen for breast cancer.
Bergman, L.; Beelen, M. L. R.; Gallee, M. P. W.; Hollema, H.; Benraadt, J., and van LeeuwenF. E.. Lancet. 356(9233):881-887, 2000 Sep 9.

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Aromatase Inhibitors

Combined endocrine treatment of elderly postmenopausal patients with metastatic breast cancer - A randomized trial of tamoxifen vs. tamoxifen plus aminoglutethimide and hydrocortisone and tamoxifen plu fluoxymesterone in women above 65 years of age.
Rose, C.; Kamby, C.; Mouridsen, H. T.; Andersson, M.; Bastholt, L.; Moller, K. A.; Andersen, J.; Munkholm, P.; Dombernowsky, P., and Christensen, I. J. (Reprint available from: Rose C Odense Univ Hosp, Dept Oncol DK-5000 Odense C Denmark). Breast Cancer Research & Treatment. 61(2):103-110, 2000 May.

Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: A phase II trial.
Lonning, P. E.; Bajetta, E.; Murray, R.; Tubiana-Hulin, M.; Eisenberg, P. D. Mickiewicz, E.; Celio, L.; Pitt, P.; Mita, M.; Aaronson, N. K.; Fowst, C.; Arkhipov, A.; di Salle, E.; Polli, A., and Massimini, G. Journal of Clinical Oncology. 18(11):2234-2244, 2000 Jun.

Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: Results of a phase III randomized double-blind trial.
Kaufmann, M.; Bajetta, E.; Dirix, L. Y.; Fein, L. E.; Jones, S. E.; Zilembo, N.; Dugardyn, J. C.; Nasurdi, C.; Mennel, R. G.; Cervek, J.; Fowst, C.; Polli, A.; di Salle, E.; Arkhipov, A.; Piscitelli, G.; Miller, L. L., and Massimini, G. Journal of Clinical Oncology. 18(7):1399-1411, 2000 Apr.

Cellular responses of mammary carcinomas to aromatase inhibitors: Effects of vorozole. Breast.
Christov, K.; Shilkaitis, A.; Green, A.; Mehta, R. G.; Grubbs, C.; Kelloff, G., and Lubet, R. (Reprint available from: Christov K Univ Illinois, Dept Surg Oncol 840 S Wood St,M-C 820 Chicago, IL 60612 USA). Cancer Research & Treatment. 60(2):117-128, 2000 Mar.

Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the tamoxifen or arimidex randomized group efficacy and tolerability study.
Bonneterre, J.; Thurlimann, B.; Robertson, J. F. R.; Krzakowski, M.; Mauriac, L.; Koralewski, P.; Vergote, I.; Webster, A.; Steinberg, M., and von Euler, M. Journal of Clinical Oncology. 18(22):3748-3757, 2000 Nov 15.

Formestane is feasible and effective in elderly breast cancer patients with comorbidity and disability.
Venturino, A.; Comandini, D.; Granetto, C.; Audisio, R. A.; Castiglione, F.; Rosso, R., and Repetto, L. (Reprint available from:
Venturino A PO S Lazzaro, Via P Belli 26 I-12051 Alba CN Italy). Breast Cancer Research & Treatment. 62(3):217-222, 2000 Aug.

Critique of survival update analysis from two phase III anastrozole clinical trials.
Buzdar, A. U.; Wood; Wolter; Vogel; Bland, and Ravdin. Annals of Surgical Oncology. 6(8 Suppl S):8S-11S, 1999 Dec. No abstract

Letrozole: Which dose to be used?
Buzdar, A. U. Journal of Clinical Oncology. 18(8):1802-1803, 2000 Apr. No abstract

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Faslodex® (fulvestrant, ICI182180): An estrogen receptor downregulator

Is ICI 182,780 an antiprogestin in addition to being an antiestrogen?
Zand, R. S. R.; Grass, L.; Magklara, A.; Jenkins, D. J. A., and Diamandis, E. P. (Reprint available from: Zand RSR Mt Sinai Hosp, Dept Pathol & Lab Med 600 Univ Ave Toronto ON M5G 1X5 Canada). Breast Cancer Research & Treatment. 60(1):1-8, 2000 Mar.

Selective estrogen receptor modulators: Structure, function, and clinical use [Review].
Osborne, C. K. and Fuqua, S. A. W. Journal of Clinical Oncology. 18(17):3172-3186, 2000 Sep.

Development of a novel, "pure" antiestrogen.
Howell, A.; Osborne, C. K.; Morris, C., and Wakeling, A. E. ICI 182,780 (Faslodex (TM)) -. Cancer. 89(4):817-825, 2000 Aug 15.

Similarities and distinctions in the mode of action of different classes of antioestrogens [Review].
Wakeling, A. E. Endocrine-Related Cancer. 7(1):17-28, 2000 Mar.

Approaches targeted to estrogen receptors for treatment of tamoxifen-resistant breast cancer: A brief overview.
Terakawa, N. (Reprint available from: Terakawa N Tottori Univ, Sch Med, Dept Obstet & Gynecol Yonago Tottori 683 Japan).. Oncology. 59(Suppl 1):3-4, 2000. No abstract

Treatment with the pure antiestrogen faslodex (ICI 182780) induces tumor necrosis factor receptor 1 (TNFR1) expression in MCF-7 breast cancer cells.
Smolnikar, K.; Loffek, S.; Schulz, T.; Michna, H., and Diel, P. (Reprint available from: Smolnikar K DSHS Cologne, Inst Morphol & Tumor Res Carl Diem Weg 6 D-50927 Cologne Germany). Breast Cancer Research & Treatment. 63(3):249-259, 2000 Oct.

Symposium overview: Estrogens and antiestrogens in managing the patient with breast cancer.
Newman, L. A.; Wood, W. C.; Sellin, R. V.; Morrow, M.; Vogel, C., and Singletary, S. E (Reprint available from: Singletary SE Univ Texas, MD Anderson Canc Ctr, Dept Surg Oncol 1515 Holcombe Blvd,Box 106 Houston, TX 77030 USA).. Annals of Surgical Oncology. 7(8):568-574, 2000 Sep.

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Ovarian ablation/suppression

Combined treatment with buserelin and tamoxifen in premenopausal metastatic breast cancer: A randomized study.
Klijn, J. G. M.; Beex LVAM; Mauriac, L.; van Zijl, J. A.; Veyret, C.; Wildiers, J.; Jassem, J. Piccart, M.; Burghouts, J.; Becquart, D.; Seynaeve, C.; Mignolet, F., and Duchateau, L. (Reprint available from: Klijn JGM Dr Daniel den Hoed Klin, Rotterdam Canc Inst, Dept Med Oncol Groene Hilledijk 301 NL-3075 EA Rotterdam Netherlands). Journal of the National Cancer Institute. 92(11):903-911, 2000 Jun 7.

Prevention of rat mammary carcinoma utilizing leuprolide as an equivalent to oophorectomy.
Jett, E. A.; Lerner, M. R.; Lightfoot, S. A.; Hanas, J. S.; Brackett, D. J., and Hollingsworth, A. B. (Reprint available from: Hollingsworth AB Mercy Hosp, Womens Ctr 4300 McAuley Blvd Oklahoma City, OK 73120 USA). Breast Cancer Research & Treatment. 58(2):131-136, 1999 Nov.

Combined endocrine therapy for breast cancer - New life for an old idea?
Davidson, N. E. (Reprint available from: Davidson NE Johns Hopkins Oncol Ctr 1650 Orleans St,Rm 409 Baltimore, MD 21231 USA). Journal of the National Cancer Institute 92(11):859-860, 2000 Jun 7. No abstract

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Estrogen/progesterone receptors

The effect of estrogen usage on the subsequent hormone receptor status of primary breast cancer.
Lower, E. E.; Blau, R.; Gazder, P., and Stahl, D. L. (Reprint available from: Lower EE Univ Cincinnati, Coll Med, Dept Internal Med Cincinnati, OH 45221 USA).. Breast Cancer Research & Treatment. 58(3):205-211, 1999 Dec.

Development of a novel, "pure" antiestrogen.
Howell, A.; Osborne, C. K.; Morris, C., and Wakeling, A. E. ICI 182,780 (Faslodex (TM)) -. Cancer. 89(4):817-825, 2000 Aug 15.

Time-dependent relevance of steroid receptors in breast cancer.
Coradini, D.; Daidone, M. G.; Boracchi, P.; Biganzoli, E.; Oriana, S.; Bresciani, G.; Pellizzaro, C.; Tomasic, G.; Di Fronzo, G., and Marubini, E. Journal of Clinical Oncology. 18(14):2702-2709, 2000 Jul.

Hormonal receptor determination of 1,052 Chinese breast cancers.
Chow, L. W. C. and Ho, P. Journal of Surgical Oncology. 75(3):172-175, 2000 Nov.

Youth and hormone receptors in breast cancer: good or bad news first?
Stockler, M. and Beith, J. (Reprint available from: Stockler M Univ Sydney, Natl Hlth & Med Res Council, Clin Trials Ctr, Dept Med Sydney NSW 2006 Australia). Lancet. 355(9218): 1839-1840, 2000 May 27. No abstract

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