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As world demographics change and the population of women over the age of 65 grows, optimal treatment of the elderly breast cancer patient becomes an increasingly important issue. The median age of breast cancer diagnosis is 64; however, many key questions in the treatment of elderly women remain. What are the age biases in clinical decision-making, and are they valid? What is the optimal chemotherapy regimen for elderly women in both the adjuvant and metastatic settings? What are the differences in surgical treatments of elderly women? Why are fewer elderly women enrolled in clinical trials? INTERGROUP TRIAL OF ADJUVANT CHEMOTHERAPY IN OLDER WOMEN We are currently close to launching a trial for women age 65 and older who have either node-positive or high-risk, node-negative breast cancer. Patients will be randomized to either capecitabine or standard therapy with either CMF or CA. This will be an equivalence trial to see if oral capecitabine for six courses is equivalent to either CMF or CA. Quality of life and the influence of co-morbidity on outcome will also be studied, as will the functional status of the patients. Were very excited about this, because we believe that if capecitabine is equivalent to more intensive regimens, it might be very attractive for many patients as an adjuvant regimen. I believe that a lot of physicians will be willing to put patients on this trial. The patients are there, and I feel confident we will meet accrual. If you look at Phase II trials in metastatic breast cancer as second- and third-line therapies, there is now a reasonable database for capecitabine demonstrating response rates of about 20 to 30%, which really is comparable to taxanes, vinorelbine and other very active agents. So, if you look at capecitabine as a single agent, it fits in. Taxanes have been extensively compared to regimens like CAF and CMF and have proven to be as good, if not superior, and so if you take a Boolean approach, capecitabine should be reasonable to consider for an equivalence trial to CA or CMF. There is also a very small comparison of capecitabine versus CMF in metastatic disease where the response rate was higher, although not significantly, for capecitabine. Hyman Muss, MD TREATING THE ELDERLY WITH CHEMOTHERAPY: FINDING A LESS TOXIC REGIMEN The elderly is a group of patients that many physicians have been somewhat hesitant to treat aggressively with chemotherapy because the benefit, although statistically significant, is small in this patient population. Europeans have been very strong in using hormonal therapy instead of cytotoxics in this population. Were looking for a more gentle but reasonably active drug combination, or, in the case of capecitabine, a single drug. It is interesting to look at capecitabine as an adjuvant treatment in an elderly population, where the options currently available are rather toxic CMF, AC, etc.... Knowing that capecitabine has activity at least equivalent to CMF in advanced disease, may offer a minimally toxic regimen with benefit in a population of patients that we all are somewhat reticent to treat. Daniel Budman, MD
Balducci L. The geriatric cancer patient: Equal benefit from equal treatment. Cancer Control 2001;8(2 Suppl):1-25. Full-Text Du X, Goodwin JS. Patterns of use of chemotherapy for breast cancer in older women: Findings from Medicare claims data. J Clin Oncol 2001;19:1455-61. Abstract Extermann M et al. What threshold for adjuvant therapy in older breast cancer patients? J Clin Oncol 2000;18(8):1709-17. Abstract Gajdos C et al. The consequence of undertreating breast cancer in the elderly. J Am Coll Surg 2001;192:698-707. Abstract Kimmick GG, Muss HB. Systemic therapy for older women with breast cancer. Oncology (Huntingt) 2001;15:280-91; discussion 291-2, 295-6, 299. Abstract Muss HB. Factors used to select adjuvant therapy of breast cancer in the United States: An overview of age, race and socioeconomic status. J Natl Cancer Inst Monogr 2001;30:52-55. Abstract
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