Current breast cancer clinical trials

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Speakers

Karen H. Antman, M.D.
Professor of Medicine
College of Physicians and Surgeons of Columbia University
Chief, Division of Medical Oncology
Director, Herbert Irving Comprehensive
Cancer Center
New York, New York
Maria Grazia Daidone, Ph.D.
Unit 10 Determinants of Prognosis and Treatment Response
Department of Experimental Oncology
Istituto Nazionale Tumori
Milan, Italy
Jonas C. Bergh, M.D., Ph.D.
Professor of Clinical and Molecular Oncology
Karolinska Institute and Hospital
Stockholm, Sweden
Nancy E. Davidson, M.D.
Professor
Johns Hopkins Oncology Center
Johns Hopkins University School of Medicine
Baltimore, Maryland
John L. Bryant, Ph.D.
Associate Professor of Biostatistics
University of Pittsburgh
Director, Biostatistical Center
National Surgical Adjuvant Breast and Bowel Project
Pittsburgh, Pennsylvania
Christina Davies, MBChB, M.Sc.
ATLAS Coordinator
Clinical Trial Service Unit
Radcliffe Infirmary
University of Oxford
Oxford, United Kingdom
Gary M. Clark, Ph.D.
Professor of Medicine
Baylor Breast Center
Baylor College of Medicine
Houston, Texas
James J. Dignam, Ph.D.
Statistician
National Surgical Adjuvant Breast
and Bowel Project
Chicago, Illinois
Alan Coates, M.D., FRACP
International Breast Cancer Study Group
Chief Executive Officer
Australian Cancer Society
Sydney, New South Wales, Australia
Bernard Fisher, M.D.
Scientific Director
National Surgical Adjuvant Breast and Bowel Project
Distinguished Service Professor
University of Pittsburgh
Pittsburgh, Pennsylvania
Jack Cuzick, Ph.D.
Professor of Epidemiology
Head, Department of Mathematics, Statistics, and Epidemiology
Imperial Cancer Research Fund
London, United Kingdom
Patricia A. Ganz, M.D.
Professor, UCLA Schools of Medicine and Public Health
Director, Division of Cancer Prevention and Control Research
Jonsson Comprehensive Cancer Center
Los Angeles, California
Aron Goldhirsch, M.D.
Chairman, Scientific Committee, International Breast Cancer Study Group
Professor of Medical Oncology
Director, Division of Medical Oncology
European Institute of Oncology
Milan, Italy
Monica Morrow, M.D.
Professor of Surgery, Northwestern Memorial Hospital
Northwestern University Medical School
Director, Lynn Sage Comprehensive
Breast Program
Director of Cancer Department
American College of Surgeons
Chicago, Illinois
Richard Gray, M.A., M.Sc.
Director
Clinical Trials Unit
University of Birmingham Medical School
Birmingham, United Kingdom
Hyman B. Muss, M.D.
Associate Director, Vermont Cancer Center
Professor of Medicine, University of Vermont College of Medicine
Director of Hematology/Oncology
Fletcher Allen Health Care
University of Vermont
Burlington, Vermont
I. Craig Henderson, M.D.
Adjunct Professor of Medicine
University of California, San Francisco
San Francisco, California
Larry Norton, M.D.
Head, Division of Solid Tumor Oncology
Norna S. Sarofim Chair in Clinical Oncology
Memorial Sloan-Kettering Cancer Center
New York, New York
Gabriel N. Hortobagyi, M.D., FACP
Professor and Chairman
Department of Breast Medical Oncology
M.D. Anderson Cancer Center
University of Texas
Houston, Texas
C. Kent Osborne, M.D.
Professor
Baylor Breast Center
Baylor College of Medicine
Houston, Texas
Amy S. Langer, M.B.A.
Executive Director
National Alliance of Breast Cancer
Organizations (NABCO)
New York, New York
William P. Peters, M.D., Ph.D.
Director and Chief Executive Officer
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan

Mark Norman Levine, M.D.
Professor of Medicine
McMaster University
Hamilton, Ontario, Canada

Eleftherios P. Mamounas, M.D.
Medical Director
Cancer Center
Aultman Hospital
Canton, Ohio

Sir Richard Peto, F.R.S., M.Sc.
Early Breast Cancer Trialists’ Collaborative Group Secretariat
Professor of Medical Statistics and Epidemiology
Co-Director
ICRF/MRC Clinical Trial Service Unit and Epidemiological Studies Unit
Radcliffe Infirmary, University of Oxford
Oxford, United Kingdom
Martine J. Piccart, M.D., Ph.D.
Chairman, Breast International Group
Head, Chemotherapy Department
Jules Bordet Institute
B-1000 Brussels, Belgium
George W. Sledge, Jr., M.D.
Ballvé-Lantero Professor of Oncology
Department of Medicine
Indiana University School of Medicine
Indianapolis, Indiana

Lori Pierce, M.D.
Associate Professor
Department of Radiation Oncology
University of Michigan Medical Center
Ann Arbor, Michigan
Eric P. Winer, M.D.
Associate Professor of Medicine
Department of Adult Oncology
Dana-Farber Cancer Institute
Boston, Massachusetts

Peter Ravdin, M.D., Ph.D.
Associate Professor
Department of Medicine
Division of Medical Oncology
University of Texas Health Science
Center at San Antonio
San Antonio, Texas
Norman Wolmark, M.D.
Chairman, National Surgical
Adjuvant Breast and Bowel Project
Chairman and Professor
Department of Human Oncology
Allegheny General Hospital
Pittsburgh, Pennsylvania
Stuart J. Schnitt, M.D.
Associate Professor of Pathology
Harvard Medical School
Director of Surgical Pathology
Beth Israel Deaconess Medical Center
Boston, Massachusetts
William C. Wood, M.D., FACS
Joseph Brown Whitehead Professor and Chairman
Department of Surgery
Emory University School of Medicine
Atlanta, Georgia

 

 

 

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Contents
I.
Overview
II.
Factors Used To Select Adjuvant Therapy
III.
Adjuvant Hormone Therapy
IV.
Adjuvant Chemotherapy
V.
Adjuvant Postmastectomy Radiotherapy
VI.
Influences of Treatment-Related Side Effects and Quality-of-Life Issues on Individual Decision-Making About Adjuvant Therapy
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